Combined diphtheria and tetanus toxoids and acellular pertussis adsorbed (DTaP), Hepatitis B recombinant (Hep B), and inactivated polio virus vaccine (IPV).
Dose & Route
0.5 ml given IM
*Pediarix may only be used in children younger than age 7
Dose Recommended Age
Dose 1…..2 months
Dose 2…..4 months
Dose 3…..6 months
Pediarix® cannot be used for booster doses. The DTaP series (doses #4 and #5) and the IPV series (dose #4) must be completed with single antigen vaccines
Dose Minimum Interval and Ages
Dose 1….6 weeks of age
Dose 2….4 weeks after dose 1 (10 weeks of age)
Dose 3….8 weeks after dose 2 and 16 weeks after dose 1 and at least 24 weeks of age
- Anaphylactic reaction following a prior dose of Pediarix® or any of its component vaccines.
- Hypersensitivity to any component of the vaccine including yeast, neomycin and polymyxin B.
- History of encephalopathy within 7 days of a previous dose of any pertussis-containing vaccines.
- Progressive neurologic disorder, including infantile spasms, uncontrolled epilepsy or progressive encephalopathy.
- Guillain-Barre` syndrome (GBS) within 6 weeks after a previous dose of tetanus toxoid-containing vaccine.
- Defer vaccination in children with moderate or severe acute illness until illness subsides.
- Precautions applying to any of the component vaccines.
- Latex sensitivity
- ACIP continues to recommend the birth dose of single antigen Hep B vaccine and has approved Pediarix™ to complete the Hep B series regardless of the mother’s HBsAg status, provided the minimal age and time intervals for Hep B are observed.
- It is permissible to administer 4 doses of hepatitis B vaccine when Pediarix is used following a birth dose of hepatitis B vaccine. However, a dose of Hepatitis B vaccine must be administered on or after 24 weeks of age.
- Pediarix™ may be given simultaneously with any other vaccine(s) at separate sites.
- Pediarix™ can be used interchangeably if necessary with single antigen components (DTaP, IPV, Hep B) as long as minimal ages and intervals are observed.