A Clinician’s Handbook for Childhood & Adult Immunizations in Georgia

Meningococcal (MenACWY)

Meningococcal Conjugate Vaccine (MenACWY)


  • Bacteria
  • Direct contact with large droplet respiratory secretions transmission
  • Incubation 3-7 days

Vaccine Description

  • Inactivated conjugate vaccine, containing N. meningitidis serogroups A, C, Y, and W-135
  • Menactra® – Minimum age 9 months
  • Menveo® – Minimum age 2 months bivalent meningococcal conjugate vaccine and Haemophilus influenza type b conjugate vaccine Hib-MenACWY approved for use in ages 6 weeks through 18 months.
  • Menveo® – Newly licensed Menveo one-vial (all liquid) formulation should not be administered before age 10 years.
  • MenQuadfi® – Minimum age 2years

Dose & Route

0.5 mL given IM

Administration Schedule/Dose

  • Routine: 2-dose series at 11-12 years, 16 years
  • Catch-up: Age 13-15 years 1-dose now and booster at age 16-18 years (minimum interval 8 weeks).
  • Age 16-18 years: 1-dose

Special Populations

*For booster doses among persons with high-risk conditions refer to http://www.cdc.gov/mmwr/volumes/69/rr/rr6909a1.htm

  • Anatomical or functional asplenia (including sickle cell disease)
  • HIV infection
  • Persistent complement component deficiency
  • Complement Inhibitor
  • Eculizumab or Ravulizumab use
  • Travel to or live in countries where meningococcal disease is hyperendemic or epidemic meningococcal disease, including countries in the African meningitis belt or during Hajj
  • At risk from a meningococcal disease outbreak attributed to serogroup A, C, W, or Y
  • Microbiologists routinely exposed to Neisseria meningitidis

Special Instructions

  • MenACWY may be administered during pregnancy if indicated.
  • Because vaccinees may develop syncope, sometimes resulting in falling with injury, observation for 15 minutes after administration is recommended. If syncope develops, patients should be observed until the symptoms resolve.
  • Menactra should be administered either before or at the same time as DTaP.