A Clinician’s Handbook for Childhood & Adult Immunizations in Georgia

Influenza (IIV)

Recombinant Influenza (RIV) and cell culture-based (ccIIV)

Pathophysiology

  • Virus
  • Highly contagious
  • Respiratory transmission
  • Virus shed in respiratory secretions for 3-10 days

Dose & Route

Administer an age-appropriate formulation and dose of influenza vaccine intramuscularly annually. 

Vaccine Description

  • IIV 3 – Trivalent -Inactivated, split-virus vaccine composed of 3 virus strains two types A and one type B
  • IIV4 -Quadrivalent -Inactivated, split-virus vaccine composed of 4 virus strains two types A and two type B
  • RIV3 – Recombinant influenza vaccine trivalent
  • RIV4 – Recombinant Influenza vaccine trivalent
  • ccIIV4 – cell culture based

Brand Information

Fluzone® sanofi-pasteur (IIV4) (0.25 mL)
Approved for persons 6 months through 35 months

Fluzone® sanofi-pasteur (IIV4)  (0.5  mL)
Approved for persons 36 months and older

Fluzone High Dose® sanofi-pasteur (IIV4) (0.7 mL)
Approved for persons 65 years and older

Afluria® Seqirus (IIV4) (0.25 mL)
Approved for persons 6 months through 35 months

Afluria® Seqirus (IIV4) (0.5 mL)
Approved for person 36 months and older

Fluarix™ GSK (IIV4) (0.5 mL)
Approved for persons 6 months of age and older

FluLaval ™ GSK (IIV4) (0.5 mL)
Approved for persons 6 months of age and older

Flublok® (RIV4) (0.5mL)
Approved for persons 18 years and older

Flucelvax® Seqirus (ccIIV4) (0.5 mL)
Approved for persons 2 years and older

Fluad™ Seqirus (aIIV4) (0.5 mL)
Approved for persons 65 years and older

Recommendations

Annual influenza vaccination is recommended for all people ages 6 months and older.

Contraindications

  • Severe allergic reaction (e.g., anaphylaxis) after previous dose of any influenza vaccine or to a vaccine component, including egg protein.
  • Moderate or severe acute illness with or without fever.
  • History of Guillain-Barre Syndrome (GBS) within 6 weeks of previous influenza vaccination.

Special Considerations

The best time to give influenza vaccine is October – November; however, influenza vaccine can be administered through May.

It takes approximately 2 weeks for influenza vaccine to be protective. Immunity from influenza vaccine rarely exceeds 1 year and the vaccine virus strains may vary each year.

Download - Influenza IIV Pdf