Administration Schedule

Dose               Recommended age             Minimal Interval

1…………………..Birth………………………………*Monovalent HepB vaccine only

2…………………..1-2 months…………………..4 weeks from dose 1

3…………………..6-18 months…………………At least 8 weeks after 2nd dose and at least 16 weeks after 1st dose and infants must be at least 24 weeks of age

• All children and adolescents < 19 years and not previously vaccinated with hepatitis B series based on shared clinical decision making should be vaccinated at the earliest opportunity.
• It is permissible to administer 4 doses of hepatitis B vaccine (e.g., when combination vaccines are given after the birth dose).
• Adolescents and adults (≥ 18 years) may receive a 2- dose series of Hep B (Heplisav-B) at least 4 weeks apart.
• Adolescents and adults (≥ 18 years) may receive a 3- dose series of Hep B (PreHevbrio) on a 0-, 1- and 6-month schedule.
• Adults aged ≥ 20 years at risk for hepatitis B infection or lack a risk factor but want protection should receive 1 mL x 3 doses typically given at 0, 2 & 6 months.

Contraindications

• Anaphylactic reaction following a prior dose of HepB.
• Persons with hypersensitivity to yeast, yeast products or any vaccine component.
• Defer vaccination in persons with moderate or severe acute illness until illness subsides.
• Prefilled syringes might contain natural rubber latex, which might cause allergic reactions in persons who are latex-sensitive.
• The safety and effectiveness of Heplisav-B and PreHevbrio have not been established in adults on hemodialysis.
• Data are not available to assess the effects of Heplisav-B and PreHevbrio on breastfed infants or on maternal milk production and excretion.
• Data on Heplisav-B and PreHevbrio are currently insufficient to inform vaccine-associated risks in pregnancy. Thus, providers should vaccinate pregnant persons needing HepB vaccination with Engerix-B, Recombivax HB, or Twinrix.